Antibacterial Activity of Salvia reuterana Constituents
Document Type : Original Article
Abstract
Two flavonids: 5-hydroxy-6,7,4 ́-trimethoxy flavone (salvigenin), 5-hydroxy-7,4 ́-dimethoxy flavone (thitonine) and a labdane type diterpenoid: 8,13-epoxy-14 labdene (manoyl oxide) isolated from the solvent extract of the aerial part of Salvia reuterana Boiss.The proposed structure were stablished by 1HNMR, 13CNMR, 2DNMR( C-H-Cosy, HMQC),DEPT and Mass spectroscopy and confirmed in accordance with bibiliographic data and computational chemistry results. The three components were evaluated against 7 microorganisms including gram(+/-)bacterias by measurment of growth inhibitory zone. They showed significant effect specially on gram(-) bacterias and in this way the most effective component was thitonine which was even more effective than Gentamicine as standard antibiotic.
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