One-pot synthesis of Benzimidazole derivatives under microwave Irradiation and solvent-free condition
Document Type : Original Article
Abstract
A simple, fast, efficient and environmentally friendly method for synthesis of benzimidazole and its 2-alkyl, aryl and heteroaryl substituted derivatives was developed using zeolite HY. Two component cyclolcondensation of 1,2-phenylenediamine (o-phenylenediamine) and commercially available carboxylic acids catalyzed by zeolite HY without any solvent, under microwave irradiation led to formation of 1H-benzimidazole and 2-substituted derivatives in high yields and purity. The similar reaction was not applicable to the preparation of benzimidazole and its 2-alkyl, aryl and heteroaryl substituted derivatives. All the synthesized compounds were characterized by 1H-NMR, IR, Mass and CHNS analysis.
(2013). One-pot synthesis of Benzimidazole derivatives under microwave Irradiation and solvent-free condition. Journal of Pharmaceutical & Health Sciences, 1(2), 111-114.
MLA
. "One-pot synthesis of Benzimidazole derivatives under microwave Irradiation and solvent-free condition". Journal of Pharmaceutical & Health Sciences, 1, 2, 2013, 111-114.
HARVARD
(2013). 'One-pot synthesis of Benzimidazole derivatives under microwave Irradiation and solvent-free condition', Journal of Pharmaceutical & Health Sciences, 1(2), pp. 111-114.
VANCOUVER
One-pot synthesis of Benzimidazole derivatives under microwave Irradiation and solvent-free condition. Journal of Pharmaceutical & Health Sciences, 2013; 1(2): 111-114.
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